The Complex Rehabilitation Effectiveness of Patients with Chronic Pancreatitis and Chronic Viral Hepatitis C

Abstract

Aim: To investigate the parameters of the functional state of the pancreas in chronic pancreatitis in the background of chronic viral hepatitis C, as well as their dynamics under the influence of complex therapy with the inclusion of complex bioregulatory drugs. Materials and Methods: 106 patients were examined: patients with CP in remission, patients with CP in remission in combination with HCV in remission, and after antiviral therapy. Patients with CP and concomitant HCV were divided into two groups according to correction programs. Group I (36 patients) received only conventional treatment: antispasmodics and/or prokinetics, enzyme preparations, proton pump inhibitors, hepatoprotectors in the mode “on-demand”. Group II (36 patients), in addition to conventional treatment, received additional complex bioregulatory drugs. Results: After treatment, there was an improvement in coprogram results and an increase in fecal elastase-1 levels. Positive dynamics was observed in both groups, but in patients of group I it was statistically insignificant (p>0.05), while in the group of patients who additionally received complex of bioregulatory drugs, the changes were more pronounced: in group II the level of fecal elastase-1 increased by 52.79% (p<0.05). Conclusions: This indicates a statistically significant effect of treatment using a complex bioregulatory corrector of exocrine insufficiency (Momordica Compositum: 1 ampoule 2.2 ml intramuscularly 3 times a week №10) and a complex bioregulatory hepatotropic drug (Hepeel: 1 tab. sublingually 3 times a day 15-20 minutes before meals or 1 hour after meals for 1 month).