Peculiarities of Rehabilitation of Patients with Chronic Cerebral Circulation Insufficiency During the War

Abstract

Aim: To improve the clinical diagnosis of CCCI and to develop methods of personalized treatment and rehabilitation of patients with CCCI during the war. Materials and Methods: 38 patients were examined in age range from 49 to 73 years with diagnosis of CCCI and comorbidity, stressed during the war – 16 males і 22 females. Informed participation consent was obtained from all patients. The diagnosis was confirmed by the data of general clinical, neurological examination, neuroimaging techniques, instrumental, laboratory and neuropsychological testing – Mini-Mental State Examination (MMSE), Depression, Anxiety And Stress Scale-21 (DASS-21), Fatigue Assessment Scale (FAS) and Modified Assessment Of Neurological And Neuropsychological Deficit Scale (MANND) Results: As a result of the examination of 38 patients with a diagnosis of CCCI and comorbidity using such scales as MANND, MMSE, DASS-21, FAS and provided treatment through combination of acetylcholinesterase inhibitors and choline precursors, data were obtained on decreasing severity of neurological symptoms, regression of anxiety and depression indicators, and the most significant regression of stress and fatigue indicators. Conclusions: Therapeutic regimen should be personalized, taking into account a wide range of complaints, assessment of neurological and neuropsychological deficit, and management of chronic diseases. The appointment of acetylcholinesterase inhibitors in combination with choline precursors as targeted cholinergic insufficiency correction leads to reduction of asthenic syndrome, indicators of stress, depression and anxiety.