The Rehabilitation of the Nasopharyngeal Microbiome in Patients with Chronic Nasopharyngitis

Abstract

Aim: To evaluate the effect of immunorehabilitation therapy of CNP associated with Epstein-Barr virus on the nasopharyngeal microbiome changes and related to them indications for surgery. Materials and Methods: 20 healthy individuals and 32 patients diagnosed with CNP associated with Epstein-Barr virus were included in the study. The qualitative composition of microbiome and its quantitative characteristics were studied during the course of immunorehabilitation therapy with the phytoextract BNO 1030. The findings were compared with the features of the course of disease and existence of indications for surgical treatment. Results: In patients with indications for adenotomy, a nasopharyngeal dysbiosis was formed through elimination of commensal bacteria and contamination of nasopharynx with opportunistic and pathogenic bacteria, Candida fungi. The immunorehabilitation therapy helped 75% patients gain a pronounced clinical response and refuse operative treatment. The qualitative and quantitative composition of commensal flora, reduction in the rate of opportunistic flora and elimination of pathogenic and fungal flora were observed in such patients. In 25% patients with poor therapeutic efficacy and indications for adenotomy against the background of elimination of pathogenic and fungal flora, the level of commensal and opportunistic flora of nasopharynx remained unchanged. Conclusions: The immunorehabilitation helps 75% patients normalize the microbiome of nasopharynx, improve the clinical symptomatology and cancel the indications for surgical treatment.