Affiliation:
1. IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE
Abstract
The aim: Of this study was to improve the efficiency of complex medicamental treatment of generalized periodontitis (GP) in patients with concomitant CAD using of differentiated
immunotropic therapy, especially herbal medicine «Immuno-ton».
Material and methods: 130 patients with GP were observed (43 without and 81 with chronic CAD – stable angina, functional classes II-III (CCS)) with detection of oral hygiene
indices for Green-Vermillion, inflammation of gums PMA, bleeding of gums PBI, depth of periodontal pockets (determined by direct method). The levels of TNF-α and sPECAM-1
in gingival fluid were detected by ELISA method.
Results: The following article is dedicated to studying on the effectiveness of the proposed method of GP I and II degree of development treatment in patients with a concomitant
coronary artery disease (CAD) using of herbal medicines with immunomodulating effect. The offered methods provide disappearance of clinical signs of inflammation in the
periodontal tissues and prevention of inflammation recurrence in the long terms. Also, it was proved that usage of the forward method of the GP immunotropic therapy with
including of herbal immunomodulators leads to normalization of dynamics of tumor necrosis factor –alfa (TNF-α) and soluble platelet-endothelial cell adhesion molecule -1
(sPECAM-1) in oral fluid of abovementioned contingent of patients.
Conclusions: The progression of generalized periodontitis in patients with stable coronary heart disease is accompanied with manifestation of systemic inflammation, which
have been reduced by immunomodulator Immuno-Ton and extratemporal gel with “Enterosgel” and herbal concentrate “Dzherelo”.
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