THE ROLE OF THROMBOSIS RISK SCALES LIKE PROGRESSION PREDICTORS OF COVID-19-ASSOCIATED PNEUMONIA

Abstract

The aim: To determine the risk factors for progression by establishing the diagnostic and prognostic role of PPS and ISTH DIC score in patients with COVID-19 required hospitalization. Materials and methods: Main group was 130 patients with COVID-19, divided depending on the severity into 3 subgroups. Patients were examined twice. On visit 1 and visit 2 (after 7–14 days after hospitalization). Were provided: physical examination, lung ultrasound (LUS), laboratory tests (D-dimer, coagulogram). Were counted PPS and ISTH DIC score. Non-parametrical statistic, ROC analysis. Results: The level of D-dimer was significantly elevated in the examined patients and correlated with the severity of the disease. The number of points on the scales ISTH DIC and Padua had a significant difference between the subgroups. The maximum number of points was obtained by patients of subgroup 3, which indicates the maximum risk of thrombotic complications, as well as DIC. The ROC analysis showed that among coagulation parameters the most sensitive and specific factors associated with the progression of the clinical course is the D-dimer at admission. Conclusions: Thus, the determination of D-dimer, fibrinogen, as well as usage of the DIC and Padua scales is a useful tool not only to estimate the severity of COVID-19, but also to predict the prognosis. Thus, the level of D-dimer above 260 ng/ml, as well as the presence of three or more points on the DIC scale and/or five or more points on the Padua scale in patients with COVID-19 during hospitalization significantly increases the risk of progression clinical process.