CORRELATION OF CARDIAC BIOMARKERS WITH THE LEVELS OF SELENIUM AND ANTIOXIDANT ENZYMES IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND A HISTORY OF HYPERTENSION

Abstract

The aim: To determine the interrelations between the levels of antioxidant enzymes, selenium and the markers of myocardial injury in patients with non-ST segment elevation myocardial infarction and a history of antecedent arterial hypertension. Materials and methods: A total of 72 patients with non-ST segment elevation myocardial infarctionwere examined (42 with antecedent hypertension - group 1; 30-without hypertension – group2). Results: Patients of group 1 were characterized by significantly higher troponin I levels (p = 0.006), creatine kinase MB levels (p=0.008) and lower levels of superoxide dismutase (p=0.005), catalase (p=0.003) and selenium (p=0.008) as compared with group 2. In both groups, the activity of superoxide dismutase had an inverse correlation with troponin I: (r = -0.46, p = 0.005) and (r = -0.38, p = 0.004), respectively. A significant inverse relationships were found between selenium levels and both markers of myocardial injury in group 1 (p≤0.009), whereas in group 2 a weak correlation was found between the levels of selenium and troponin I only (p=0.006). Conclusions: The obtained data suggest that the levels of selenium and antioxidant enzymes in blood of all patients with non-ST elevation myocardial infarction inversely correlate with cardiac biomarkers. Patients with non-ST elevation myocardial infarction and a history of hypertension have significantly lower levels of antioxidant agents, higher levels of markers of myocardial injury, and stronger connections between them, indicating the development of more significant myocardial injury.