SPECIFICS OF THE ECZEMA PATIENTS` IMMUNE SYSTEM DEPENDING ON THE CLINICAL COURSE OF DERMATOSIS

Abstract

The aim: Definition of the systemic immunity cellular components and autoimmune factor in eczema patients depending on the clinical manifestations of dermatosis. Materials and methods: The study involved 95 eczema patients. 29 of them were diagnosed the true dermatosis form, while 39 and 27 subjects had infectious (microbial) and infectious (mycotic) form of the disease, accordingly. The control group consisted of 30 healthy individuals. CD3+, CD4+, CD8+, CD16 +, CD22 + and CD 95+ cells and autoantibodies to TPO and TG were counted. Results: The eczema patients present uniform, but somewhat labile changes in the state of the immune system. For example, cellular disorders, except for CD8+ count, do not statistically significantly depend on the clinical form of dermatosis, the severity of inflammatory process, and the duration of the disease. At the same time, the decrease of CD8+ count in infectious (mycotic) form of the disease and in acute and subacute course reflects a certain variability of changes in cellular immunity with intact values in true and infectious (microbial) genesis and chronic manifestations of eczema. Conclusions: Eczema patients should be subjected to valuation of cellular components of the systemic immunity and autoimmune profile. The CD8 + count of eczema patients can serve as one of the “conditional markers” of a degree of involvement of systemic immunity in the progression of eczema. Therapy of eczema patients should include medicines that possess a wide range of immunomodulatory effect.