NEUROPHYSIOLOGICAL FEATURES OF THE NOCICEPTIVE TRIGEMINAL PATHWAY IN ABDOMINALLY OBESE MIGRAINEURS

Abstract

The aim of this study were to assess clinical (cutaneous allodynia) and neurophysiological (R2 nBR component) markers of the nociceptive trigeminal-cervical pathway sensitization in the abdominally obese patients with episodic (EM) and chronic migraine (CM). Materials and methods: It had been recorded nBR within interictal period in 79 migraineurs with EM and CM who had abdominal obesity (AO) and normal body weight (NBW). Results: Patients with EM and AO had significantly lower pain thresholds than patients with EM and NBW – 0,55 (0,34-0,63) μV vs 0,70 (0,59-1,03) μV. The mean latency of R2 nBR component was significantly decreased in patients who had EM and AO (36,59 (31,95-42,41) ms) compared to patients who had EM and NBW(46,75 (42,93-52,34) ms). It had been revealed significant increasing of the mean amplitude of the component R2 nBR in patients who had EM and AO (158 (115-197) μV) compared to patients who had EM and NBW (124 (76-144) μV). In patients who had CM and AO, it had been found direct positive correlation between the amplitude of R2 nBR and severity of cutaneous allodynia – τ=0,4 (p=0,03), as well as found negative correlation between the latency of R2 nBR and severity of cutaneous allodynia – τ=-0,44 (p=0,02) within the interictal period of migraine. Conclusions: Neurophysiological findings may indirectly indicate faster migraine chronification in patients with EM and AO.