COMPREHENSIVE STUDY OF MANIFESTATIONS OF BRAIN TISSUE RESOLUTION IN CASE OF VARIOUS TYPES OF STROKE

Abstract

The aim: The study is to research the resolution of perifocal brain tissue at various type strokes using immunomorphology Materials and methods: The immunohistochemical study of perifocal brain tissue in 21 cases of various strokes types was condacted Results: When comparing the GFAP + astrocytes detection area at IS, HS and IS with HT, no significant difference was found. At the 1st degree of GFAP + astrocytes were in the border around the necrosis nucleus at IS and IS with HT, and at HS GFAP + astrocytes accumulated along the hematoma edge. CD34 + cells were found in most cases of strokes. Over time, cases with a larger CD34 + cells detection area increased (Kendal’s Tau = 0.512, p = 0.001) in all groups. The capillary network at HS was around the hematoma and formed a gliomesodermal capsule with microglia and inflammation. 1st degree τ-protein accumulation was detected in 2/3 of cases (66.7%) of all strokes without significant difference. If compared in different stroke periods, τ-protein detection frequency increased and accumulated in brain structures – Kendal’s Tau = 0.359; p = 0.023. Conclusions: With the development of the disease, the number of cases with a larger area of detection of GFAP + astrocytes and CD34 + cells increased in strokes of various types. Ʈ-protein was detected in neurons in all variants of ACVA in the first period.