Affiliation:
1. DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY, LVIV, UKRAINE
Abstract
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The aim: To determine a possible role of nitric oxide system as one of the pathogenesis links in Stevens-Johnson syndrome depending on the severity of disease progression.
Material and methods: We examined 11 patients with Stevens-Johnson syndrome. The function of nitric oxide system (NO - NOS) in blood serum was examined.
Results: During the study of nitric oxide system (NO-NOS) in patients with SJS, it was observed that NO2¯ level was increased by 1.53 times, NO3¯ level – by 3.33 times, activity of total NOS – by 5.78 times, constitutive (cNOS) – by 1.81 times and inducible (iNOS) – by 13.36 times.
Conclusions: The intensity of nitric oxide system function was studied in patients with Stevens-Johnson syndrome and dependence of changes of its parameters from the clinical signs of disease was detected. It was found that the determination of nitrite and nitrate anion levels in blood serum can be used for the purpose of predicting the disease course and choosing the therapy methods for the patients with SJS.
Reference24 articles.
1. 1. Kaliuzhnaia L.D., Turyk L.D. Stevens-Johnson syndrome in a patient with severe relapsing course of the subcorneal pustular dermatosis (Sneddon- Wilkinson disease). Ukrainian Journal of Dermatology, Venereology and Cosmetology. 2017; 3: 91-96.
2. 2. Uts S.R., Bakulev A.L., Morrison A.V. et al. A clinical case of Stevens- Johnson syndrome in a patient with pustular psoriasis. Saratov Scientific and Medical Journal. 2017; 13(3): 646-648.
3. 3. Melikian A.L., Subortseva I.N., Kovrigina A.M. et al. Stevens-Johnson syndrome after Rituximab treatment in a patient with the small lymphocytic B-cell lymphoma, autoimmune hemolytic anemia and antiphospholipid syndrome. Clinical Oncohematology. Fundamental Research and Clinical Practice. 2017; 10(1): 120-127.
4. 4. Lepehova A.A., Allenova A.S., Olisova O.Yu. et al. Comparative evaluation of the efficiency of different methods of treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis based on the literature data. Bulletin of Russian Academy of Medical Sciences. 2019; 74(3): 157-166.
5. 5. Lerch M., Mainetti C., Beretta-Piccoli Terziroli B. et al. Current Perspectives on Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Clin Rev. Allergy Immunol. 2018; 54(1): 147-176. doi: 10.1007/s12016-017- 8654-z.
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