ASSISTED REPRODUCTIVE TECHNOLOGY EFFICIENCY IMPROVEMENT OF TUBAL-PERITONEAL INFERTILITY

Abstract

The aim: This study aims to develop and implement a complex of pregravid preparation based on endogenous melatonin level, development of oxidative stress and violation of apoptosis regulation in women with tubal-peritoneal infertility. Materials and methods: We have examined 100 women of reproductive age, including 65 women with tubal-peritoneal infertility treated by ART. All studied women were defined levels of endogenous melatonin, oxidative status and level of apoptosis in the endometrium and in follicular fluid (infertile women only). As a powerful free radical neutralizer, we used melatonin to improve the microenvironment of maturing oocytes and create favourable conditions for implantation in the endometrium. Results: Treatment by exogenous melatonin showed better results than standard therapy without antioxidants: the quality of oocytes and embryos, the level of ongoing pregnancies and childbirth was significantly higher. Conclusions: We achieved such results due to restoring the balance in pro / antioxidant system and apoptosis in female reproductive tract.