PREGNANCY OUTCOMES IN WOMEN WITH EXTREMELY HIGH SFLT-1/PIGF RATIO: CASE SERIES-Reference-Cited by-同舟云学术

PREGNANCY OUTCOMES IN WOMEN WITH EXTREMELY HIGH SFLT-1/PIGF RATIO: CASE SERIES

Published:2022-01 Issue:1 Volume:75 Page:141-143
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Oshovskyy Viktor¹,Arbuzova Svitlana²,Nikolenko Marharyta³,Mylytsya Kostyantyn⁴

Affiliation:

1. UNIKLINIKA MEDICAL CENTRE, KYIV, UKRAINE

2. CENTER OF MEDICAL GENETICS AND PRENATAL DIAGNOSIS, KYIV, UKRAINE

3. MEDICO-BIOLOGICAL CENTER “GENOM”, KYIV, UKRAINE

4. MULTIDISCIPLINARY CLINIC OF THE ST. NICHOLAS, ZAPORIZHZHIA, UKRAINE

Abstract

Preeclampsia (PE) is a multisystem disorder, usually defined as the development of hypertension and proteinuria after 20 weeks of pregnancy. The sFlt-1/PlGF ratio has been widely studied as a diagnostic and prognostic marker of preeclampsia and other manifestations of placental dysfunction. A sFlt-1/PlGF ratio greater than 85 for early PE, <34 weeks of gestation suggests a high risk of PE requiring close clinical monitoring. Our main aim was to evaluate the maternal and perinatal outcomes of pregnancies with an extremely high sFlt-1/PlGF ratio. The analysis included data on placental growth factor and soluble fms-like tyrosine kinase serum levels, measured during 2017–2020 in 128 pregnant women. Here we present 8 cases of women with a numerical ratio greater than 850. In all 100% of cases, the signs of obstetric angiogenic catastrophe requiring imminent delivery developed soon. We observed a trend for worsening perinatal outcomes in women with an extremely high sFlt-1/PlGF of ≥850.

Publisher

ALUNA

Subject

General Medicine

Reference14 articles.

1. 1. Robertson S.A. Preventing Preeclampsia by Silencing Soluble Flt-1? N Engl J Med. 2019;380(11):1080–1082.

2. 2. Stolz M., Zeisler H., Heinzl F. et al. An sFlt-1:PlGF ratio of 655 is not a reliable cut-off value for predicting perinatal outcomes in women with preeclampsia. Pregnancy Hypertens. 2018;11:54–60.

3. 3. Herraiz I., Simón E., Gómez-Arriaga P. et al. Angiogenesis-Related Biomarkers (sFlt-1/PLGF) in the Prediction and Diagnosis of Placental Dysfunction: An Approach for Clinical Integration. Int J Mol Sci. 2015;16(8):19009–19026.

4. 4. De Oliveira L., Peraçoli J.C., Peraçoli M.T. et al. SFlt-1/PlGF ratio as a prognostic marker of adverse outcomes in women with early-onset preeclampsia. Pregnancy Hypertens. 2013;3(3):191–195.

5. 5. Tsatsaris V., Fournier T., Winer N. Physiopathologie de la prééclampsie. Ann Fr Anesth Reanim. 2010;29(3):e13–e18.