MORPHOLOGICAL CHANGES OF THE ENDOMETRIUM IN HYPERPLASTIC PROCESS IN WOMEN OF REPRODUCTIVE AGE-Reference-Cited by-同舟云学术

MORPHOLOGICAL CHANGES OF THE ENDOMETRIUM IN HYPERPLASTIC PROCESS IN WOMEN OF REPRODUCTIVE AGE

Published:2021 Issue:3 Volume:74 Page:388-394
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Vereshchahina Tetiana V.¹,Boychuk Alla V.¹,Yakymchuk Yuliia B.¹,Nikitina Iryna M.²,Datsko Tetiana V.¹

Affiliation:

1. I. YA. HORBACHEVSKY TERNIOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

2. SUMY STATE UNIVERSITY, SUMY, UKRAINE

Abstract

The aim: To conduct a morphological study of endometrial tissue to identify changes characteristic of viral lesions to develop improved antirelapse treatment of HPE in women of reproductive age. Materials and methods: We surveyed 90 patients of the gynecological department who sought medical for hyperplastic processes of the endometrium in reproductive age. All women underwent hysteroscopy, the resulting material was subjected to morphological examination. Results: It became known that the virus is involved in the pathogenesis of endometrial hyperplasia. It is likely that it exists in epitheliocytes not only as a “passenger”, but also as an etiological factor. It became known that it was in complex hyperplasia with atypia that the percentage reached the highest level, which is a precancerous condition. Conclusions: Typical morphological change of the endometrium – multinucleation, multinuclearity and koilocytotic atypia in women of childbearing age with HPE – was revealed. The presence of infectious pathogens in the endometrium of patients with HPE can be regarded as one of the possible triggers for the development of hyperplastic processes.

Publisher

ALUNA

Subject

General Medicine

Reference36 articles.

1. 1. Akrish S., Eskander-Hashoul L., Rachmiel A., Ben-Izhak O. Clinicopathologic analysis of verrucous hyperplasia, verrucous carcinoma and squamous cell carcinoma as part of the clinicopathologic spectrum of oral proliferative verrucous leukoplakia: A literature review and analysis. Pathol. Res. Pract. 2019;215(12):152670. https://doi.org/doi:10.1016/j.prp.2019.152670.

2. 2. Farhane F.Z., Alami Z., Bouhafa T. et al. Primary squamous cell carcinoma of endometrium: case report and literature review. Pan Afr. Med. J., 2018;4 (30):8. https://doi.org/doi:10.11604/pamj.2018.30.8.8983.

3. 3. Boichuk A.V., Shadrina V.S., Vereshchahina T.V. Hyperplasia of endometrium – a modern system-pathogenetic view on the problem (literature review): (literature review). Actual problems of pediatrics, obstetrics and gynecology, 2019;(1):67-72. https://doi.org/10.11603/24116-4944.2019.1.9906.

4. 4. Upadhyaya J.D., Fitzpatrick S.G., Islam M.N., et al. A retrospective 20- year analysis of proliferative verrucous leukoplakia and its progression to malignancy and association with high-risk human papillomavirus. Head. Neck. Pathol., 2018;12(4):500-510. https://doi.org/doi:10.1007/s12105-018-0893-7

5. 5. Li P., Ma J., Zhang X. Et al. Cervical small cell carcinoma frequently presented in multiple high risk HPV infection and often associated with other type of epithelial tumors. Diagn. Pathol., 2018;13(1):31. https://doi.org/doi:10.1186/s13000-018-0709-9.

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