ASSOСIATION BETWEEN VITAMIN D STATUS AND METABOLIC DISORDERS IN PREMENOPAUSAL WOMEN WITH AUTOIMMUNE HYPOTHYROID DISEASE

Abstract

The aim: Is to establish a relationship between serum vitamin D level with carbohydrate and lipid indexes in women with autoimmune hypothyroid disease. Materials and methods: 146 women with autoimmune hypothyroid disease were examined in the period 2017-2019, who signed the informed consent. The mean age of women was 43.8 ± 0.7 years. Anthropometric, general clinical and biochemical examinations were performed including determination of lipid metabolism, hydrocarbon metabolism and establishment of vitamin-D status. Results: Vitamin D deficiency was found in 78.8%, insufficiency in 17.1% of women with autoimmune hypothyroidism. Statistical processing of results was carried out and established strong negative correlation between 25 (OH) D and Thyroid Peroxidase Antibody (r = -0,77) and thyrotropic hormone level (r = -0.72), р<0,05. Strong inverse correlations were found between vitamin D levels and body mass index (r=-0,74) and total cholesterol levels (r=-0,72), negative correlation of medium strength was with highdensity lipoprotein cholesterol (r=-0,58), triglycerides (r=-0,46), atherogenic coefficient (r=-0,65) and the HOMA-IR (r=-0,57), The values of p < 0.05 were considered reliable. Conclusions: The incidence of vitamin D hypovitaminosis in women with autoimmune thyroid disease is significantly higher than in the healthy population. Low vitamin D status is significantly associated with autoimmune thyroid dysfunction and determines the degree of metabolic disorders and cardiovascular risk in premenopausal women with autoimmune hypothyroid disease.