QUANTITATIVE MORPHOLOGICAL ASPECTS OF THE STUDY OF THE FEATURES OF THE REMODELING OF THE HEMOMICROCIRCULATORY CHANNEL OF THE TESTICLES UNDER THE ACTION OF ALUMINUM CHLORIDE ON THE BODY-Reference-Cited by-同舟云学术

QUANTITATIVE MORPHOLOGICAL ASPECTS OF THE STUDY OF THE FEATURES OF THE REMODELING OF THE HEMOMICROCIRCULATORY CHANNEL OF THE TESTICLES UNDER THE ACTION OF ALUMINUM CHLORIDE ON THE BODY

Published:2023 Issue:12 Volume:76 Page:2668-2673
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Konovalenko Sergii¹,Kritsak Myroslav¹,Yasinovskyi Oleh¹,Pavliuk Bohdana¹,Stechyshyn Iryna¹,Diadiun Tatyana²

Affiliation:

1. НORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE

2. NATIONAL UNIVERSITY OF PHARMACY, KHARKIV, UKRAINE

Abstract

The aim: To conduct a morphometric analysis of the features of the remodeling of vessels of the hemomicrocirculatory channel of the testicles under the action of aluminum chloride on the body. Materials and methods: The testicles of 52 white male Wistar rats were morphologically studied, which were divided into two groups: intact and animals injected with aluminum chloride at a dose of 100 mg/kg. Results: The long-term effect of aluminum chloride on the body led to pronounced changes in the quantitative morphological indicators of the vessels of the hemomicrocirculatory channel of the testes compared to the control ones. The diameter of arterioles of the left testicle decreased by 18.4%, precapillary arterioles by 19.1%, hemocapillaries by 10.1%. The diameter of the postcapillary venules of the left testicle increased by 26.3%, the venules by 26.4%, and the density of microvessels decreased by 30.0%, which indicated the deterioration of its blood supply. The degree of remodeling of microvessels in the right testis was less pronounced. The diameter of arterioles of the right testicle decreased by 17.1%, precapillary arterioles by 18.4 %, and hemocapillaris by 9.1%. The diameter of the postcapillary venules of the right testicle increased by 25.5%, the venules by 27.0%, and the density of microvessels decreased by 25.8%. Conclusions: Long-term action (during the month) of aluminum chloride on the body leads to pronounced remodeling of the vessels of the hemomicrocirculatory channel of the testicles, which is characterized by a pronounced narrowing of its supply (arterioles, precapillary arterioles), exchange (hemocapillaries) links.

Publisher

ALUNA

Reference13 articles.

1. 1. Krewski D, Yokel RA, Nieboer E et al. Human health risk assessment for aluminium, aluminium oxide, and aluminium hydroxide. Journal of toxicology and environmental health. Part B, Critical reviews. 2007;10 (1):1–269. doi: 10.1080/10937400701597766.

2. 2. Hnatjuk M, Tatarchuk L, Kritsak M et al. Morphometric assessment of peculiarities of blood vessels of the testis in experimental animals at arterial hypertension in a little circle of circulation. Georgian medical news. 2021;313:163-168.

3. 3. Konovalenko S, Kritsak M, Stechyshyn I, Pavliuk B. Male infertility as a consequence of endogenous and exogenous factors. Pharmacologyonline. 2021; 3:265-274.

4. 4. Hnatyuk MS, Konovalenko SO, Tatarchuk LV. Peculiarities of vascular remodeling of hematomicrocirculatory bаd at postresection portal hypertension. Hospital surgery. 2019;0(4):37-42.

5. 5. Budniak L, Slobodianiuk L, Marchyshyn S, Ilashchuk P. Determination of polysaccharides in gentiana cruciata L. Herb. Pharmacologyonline. 2021;2:1473–1479.