CHANGES IN THE STATE OF VEGETATIVE NERVOUS SYSTEM OF ALBINO RATS AT THE BACKGROUND OF CHRONIC ROUNDUP POISONING

Abstract

The aim: The aim of this research was the study of low dose roundup, a well-known herbicide, chronic poisoning on the state of the vegetative nervous system in albino rats. Materials and methods: The state of vegetative nervous system was assessed by the method of variation pulsometry The two-week chronic roundup poisoning at a dose of 40 mcg/kg having been simulated on 30 albino rats. Results: The chronic roundup poisoning was accompanied by impaired state of vegetative nervous system that revealed itself in the growing indices of variation pulsometry: tension index – 1.6 times (P<0.001), index of regulatory system activity – 1.52 times (P<0.001), vegetative balance index – 2.36 times (P<0.001), rhythm vegetative index – 1.39 times (P<0.001). Moderate regulatory system stress, requiring extra functional reserves to provide adaptation to environment, was observed. Such condition occurs in the process of adaptation to adverse environmental factors with impairing adaptive self-regulation mechanisms. Conclusions: Internal two-week use of the roundup on albino rats in a dose of 40 mcg/kg is accompanied by functional disorders of vegetative nervous system, which reveal themselves in the growing values of variation pulsometry. The results obtained were indicative of prevailing vegetative system sympathetic division as compared with parasympathetic one, as well as of disordered regulation of vegetative nervous system tone.