MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL SIGNS OF PLACENTAL DISORDERS OF WOMEN AFTER SYPHILITIC INFECTION-Reference-Cited by-同舟云学术

MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL SIGNS OF PLACENTAL DISORDERS OF WOMEN AFTER SYPHILITIC INFECTION

Published:2022 Issue:12 Volume:75 Page:2958-2964
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Husiev Viacheslav M.¹,Khapchenkova Daria S.¹,Dubyna Serhii O.¹,Bondarenko Stanislav V.¹

Affiliation:

1. DONETSK NATIONAL MEDICAL UNIVERSITY, LYMAN, UKRAINE

Abstract

The aim: To define morphological and immunohistochemical signs of placental disorders of women after syphilitic infection. Materials and methods: The prospective study of 60 pregnant women with history of syphilitic infection (main group) and 57 pregnant patients without syphilis (control group) was conducted. The morphological and immunohistochemical study of the afterbirth was performed. Results: In the placentas of women of the main group the following phenomena were found out: circulatory disorders in the form of hemorrhages into the intervillous space and the stroma of villi; accumulation of fibrinoid around villi with dystrophically altered stroma, compensatory-adaptive reactions resulted in hyperplasia of terminal villi and vessels in them, which provoked narrowing of the intervillous space and disruption of blood supply in it. Pathogenic immune complexes containing Ig G, M and C3 of the complement fraction were located in the central part of the placenta – 45.00% of cases, 16.67% – in the regional, 8.33% – in both parts. Immune complexes with Ig M content occurred in 38.33% of cases. The content of pathogenic immune complexes was the most concentrated in the placentas of women with latent forms and secondary recurrent syphilis – 60.00% of cases. Conclusions: changes in morphohistological and immunohistochemical examination of the placenta of this group of women confirmed the detrimental effect of syphilitic infection in the anamnesis on the structure of placenta during the next pregnancies.

Publisher

ALUNA

Subject

General Medicine

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