DEVELOPMENT OF CONTINUOUS ANTI-SOLVENT RECRYSTALLIZATION METHOD TO PRODUCE CEFTRIAXONE SODIUM NANO CRYSTALS INJECTION USING CERAMIC FILTRATION-Reference-Cited by-同舟云学术

DEVELOPMENT OF CONTINUOUS ANTI-SOLVENT RECRYSTALLIZATION METHOD TO PRODUCE CEFTRIAXONE SODIUM NANO CRYSTALS INJECTION USING CERAMIC FILTRATION

Published:2021 Issue:9 Volume:74 Page:2323-2336
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Rahi Firas Aziz¹,Kadhim Mj Krar²

Affiliation:

1. AL-TURATH UNIVERSITY COLLEGE, BAGHDAD, IRAQ

2. FACULTY OF PHARMACY, UNIVERSITY OF KUFA, KUFA, IRAQ

Abstract

The aim: In this work we developed a method of continuous recrystallization to meet industrial requirements. Materials and methods: Continuous recrystallization method was investigated using porous ceramic filter for water purification with pour size less than 1 μm, that ensures high mixing rate of ethanol and water. Results and conclusions: The results of experiments using crystallization through ceramic filter, gives superior products in particle size, and produced needle shaped ceftriaxone crystals form, that showed significant improvement in dissolution time and obtained ceftriaxone sodium powder to be reconstituted in injectable formula that give clear solution without insoluble microparticles.

Publisher

ALUNA

Subject

General Medicine

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