Immunogenetic predictors of the development of bronchial obstruction during acute bronchitis in infants

Author:

Abaturov Alexandr E.1,Rusakova Olena O.1

Affiliation:

1. State Institution “Dnipropetrovsk Medical Academy Of The Ministry Of Health Of Ukraine”, Dnipro, Ukraine

Abstract

The aim: To determine the most informative immunological and molecular genetic factors which reflect the characteristics of the inflammatory process and make it possible to predict the development of bronchial obstruction during acute bronchitis in infants. Materials and methods: 120 children aged from 6 months to 3 years old with acute bronchitis were examined. We determined NF-κB expression level in peripheral blood lymphocytes by flow cytometry method, the serum concentrations of interferon-γ, interleukins 4, 12 and 13 by ELISA, total IgE serum level by ECLIA and calculated the relative risk (RR) for each of these parameters. Results: The risk of bronchial obstruction development was high when the relative number of lymphocytes expressing NF-κB was under 49.8% (RR=3.27, 95% CI=2.09-4.92). IL-12 serum concentration from 41.35 pg/ml to 173.06 pg/ml (RR=5.35, 95% CI=2.82-9.15) and IL-13 serum concentration from 4.06 pg/ml to 6.71 pg/ml (RR=4.0, 95% CI=2.39-6.41) were early predictors of the appearance of wheezing during the disease. The probability of the development of bronchial obstruction was low when the relative number of lymphocytes expressing NF-κB was above 49.8% (RR=0.40, 95% CI=0.28-0.62). NF-κB expression level above 0.91 Units (RR=0.20, 95% CI=0.11-0.39), serum concentrations of IFN-γ above 9.83 pg/ml (RR=0.50, 95% CI=0.31-0.81), IL-12 above 173.06 pg/ml (RR=0.49, 95% CI=0.30-0.82), IL-13 above 6.71 pg/ml (RR=0.40, 95% CI=0.22-0.72) reduced the probability of the appearance of wheezing significantly. Conclusions: The development of bronchial obstruction during acute bronchitis in infants is associated with the relatively low NF-κB and IL-12 levels, imbalance in IFN-γ and IL-13 production.

Publisher

ALUNA

Subject

General Medicine

Reference27 articles.

1. 1. Ministry of Health of Ukraine, GA “Ukrainian Institute of Strategic Studies”. 2017 Annual report on the state of health of the population, the sanitary-epidemic situation and the results of the health care system of Ukraine. Kyiv: IEC “Medinform”. 2018. 458 pp. [Ukrainian].

2. 2. Maydannik VG, Yemchinskaya EA. Clinical recommendations for the diagnosis and treatment of acute bronchitis in children from the position of evidence-based medicine. Kiev. 2014. 56 pp. [Russian].

3. 3. Lapshin VF, Umanets TR, Pustovalova OI. Acute obstructive bronchitis in children: the efficacy and tolerability of Prospan drops and syrup. Child’s Health. 2018;8(13):33-38. (Ukrainian).

4. 4. Bessa OA, Leite AJ, Solé D, Mallol J. Prevalence and risk factors associated with wheezing in the first year of life. J. Pediatr. (Rio J.). 2014 Mar- Apr;90(2):190-6. doi: 10.1016/j.jped.2013.08.007.

5. 5. Soloveva NA, Ilenkova NA, Smirnova SV. Bronchial obstructive syndrome in infants. Russian Pediatric Journal (Rossiiskii Pediatricheskii Zhurnal). 2014;4:32-38. (Russian).

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