EARLY METABOLIC DISORDERS AND MORPHOLOGICAL CHANGES OF INTERNAL ORGANS AFTER GASTRIC BYPASS WITH ONE ANASTOMOSIS. EXPERIMENTAL STUDY

Abstract

The aim: To investigate morphofunctional changes in bone tissue, mucous membranes of different parts of the intestine, parathyroid glands, as well as changes in blood biochemical parameters depending on the length of the common loop in modeling gastric bypass with one anastomosis within 60 days. Materials and methods: Modeling of obesity in males of white outbred rats (n = 50) which were induced high-calorie diet with high animal fat content. Weight was measured before the induced diet, 1,2,3 months after the start of the induced diet and 2 months after surgery to assess the dynamics of excess weight loss. Rats were divided into three groups: control group - 5 rats, 1st group - 10 rats, 2nd group - 10 rats, 25 rats were removed from the experiment. Results: The average weight of rats before introduction into the diet was 180.5 grams, after 3 months of induced diet reached 256.7 grams, the average weight gain was 76.2 grams (42.2%). 1 group of rats had a weight loss of -16.2% (41.7 grams), Second group had a weight loss of -20.6% (53.2 grams) 60 days after gastric bypass surgery. Conclusions: The average statistical indicators of blood tests of the second group of animals in comparison with the first group show lower levels of iron phosphorus?magnesium, total protein and albumin. The average body weight loss of the first group was -16.2% (41.7 grams), the second -20.6% (53.2 grams) with a difference of 11.7 grams, which is not significant.