HEMATOLOGICAL CHANGES AFTER INTRODUCTION OF DIFFERENT SIZES LEAD NANOPARTICLES (IN EXPERIMENT)-Reference-Cited by-同舟云学术

HEMATOLOGICAL CHANGES AFTER INTRODUCTION OF DIFFERENT SIZES LEAD NANOPARTICLES (IN EXPERIMENT)

Published:2020 Issue:9 Volume:73 Page:1982-1989
ISSN:0043-5147
Container-title:Wiadomości Lekarskie
language:en
Short-container-title:Wiad Lek

Author:

Gubar Inna V.¹,Apykhtina Olena L.²,Yavorovsky Oleksandr P.³,Kovalchuk Oleksandr I.⁴,Chukhray Svitlana M.³,Sokurenko Liudmyla M.⁵

Affiliation:

1. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE; STATE INSTITUTION KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE; EDUCATIONAL AND SCIENTIFIC CENTER "INSTITUTE OF BIOLOGY AND MEDICINE" OF TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE

2. STATE INSTITUTION KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE, KYIV, UKRAINE

3. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE

4. EDUCATIONAL AND SCIENTIFIC CENTER "INSTITUTE OF BIOLOGY AND MEDICINE" OF TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE

5. BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE; EDUCATIONAL AND SCIENTIFIC CENTER "INSTITUTE OF BIOLOGY AND MEDICINE" OF TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV, KYIV, UKRAINE

Abstract

The aim: Was to compare the changes in hematological parameters of blood in the conditions of prolonged exposure of lead sulfide nanoparticles (NP) of different sizes and of lead nitrate. Materials and methods: The study was conducted on mature male Wistar rats 160-180 g, intraperitoneally injected with Pb(NO3)2 and NP PbS of 26-34 nm and 50-80 nm in 0,94 mg/kg/day dose adjusted to lead. Toxic effects were evaluated after 1,5 months, 3 months and 1 month after exposure. The studies were performed on hematologic analyzer. Results: Changes in peripheral blood were characterized by decrease in the hemoglobin level in the blood. An increase in the total number of leucocytes was observed, which is statistically significant by the increase of number of lymphocytes and the absolute number of monocytes. Changes in the platelet number were characterized by an increase in the average volume of platelets and a decrease in the platelet heterogeneity index. Conclusions: The most pronounced changes hemoglobin level in the blood and concentration of hemoglobin in the erythrocyte were observed in the effects of PbS NP (50-80 nm), but leucocytes indicators - of PbS NP (26-34 nm) and Pb(NO3)2.

Publisher

ALUNA

Subject

General Medicine

Reference29 articles.

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