ASSOCIATION BETWEEN APE1 GENE AND LUNG CANCER IN IRAQI POPULATION

Abstract

The aim: To find association between ape1 gene and lung cancer in Iraqi population. Materials and methods: This study included forty patients with lung cancer and forty people of control group, ranging in age from 40 to 65 years old. Results: The results of (Asp/Glu) genotype showed a significant (p=<0.01) higher frequency in patients than in control group carrying the (Asp/Asp). Conclusions: APE1 Asp148Glu polymorphism may bear a risk for development of the lung cancer in Iraqi patients, and the Asp/Glu genotype contributed to more often predisposal of the disease by playing an important role as increased activity of gene as a result of APE1 Asp148Glu (rs1130409) polymorphism, while Asp/Asp genotype may have a protective action against this disease.