DERMAL ABSORPTION OF DIQUAT AND POTENTIAL OCCUPATIONAL RISK

Author:

Yastrub Tatyana O.1,Omelchuk Sergii T.2,Yastrub Andrii M.2

Affiliation:

1. STATE INSTITUTION “KUNDIIEV INSTITUTE OF OCCUPATIONAL HEALTH OF THE NATIONAL ACADEMY OF MEDICAL SCIENCES OF UKRAINE”, KYIV, UKRAINE

2. HYGIENE AND ECOLOGY INSTITUTE OF BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE

Abstract

The aim: The toxicological-hygienic assessment of dermal absorption of diquat in terms of potential risk of its bioavailability in professional use. Materials and methods: The object of the study was cutaneous exposure of diquat, determined in toxicological experiments of different duration (data of scientific literature) and at the stage of state testing of pesticide preparations based on diquat dibromide (data of a full-scale hygiene experiment, prognostic model of risk assessment), the technical concentrate of diquat dibromide (active substance content not less than 377 g / kg) contains relevant supplements, the content of which is regulated by the Food and Agriculture Organization. Results and conclusions: Due to the high risk of the diquat adverse effects affecting the personnel, general public and environment, the European Union has introduced administrative decisions to forbid plant protection products containing the diquat. Fulfillment of the conditions of the Association Agreement between Ukraine and the European Union indicates the need to develop common regulations and risk assessment methods aimed at ensuring high level of protection of human health and the environment.

Publisher

ALUNA

Subject

General Medicine

Reference17 articles.

1. 1. Buist H., Craig P., Dewhurst I., et al. 2017. Guidance on dermal absorption. EFSA Journal. 2017;15(6):4873. https://doi.org/10.2903/j. efsa. 2017.4873

2. 2. European Food Safety Authority. Conclusion on the peer review of the pesticide risk assessment of the active substance diquat. EFSA Journal. 2015;13(11):4308. doi:10.2903/j.efsa.2015.4308.

3. 3. Dopustymi dozy, kontsentratsii, kilkosti ta rivni vmistu pesticidiv u silskogospodarskii syrovyni, kharchovykh produktakh, povitri robochoi zony, atmosfernomu povitri, vodi vodoimyshch, grunti: Derzhavni sanitarni pravyla ta normy DSanPiN 8.8.1.2.3.4-000-2001 [Permissible doses, concentrations, amounts and levels of pesticides in agricultural raw materials, foodstuffs, working zone air, atmospheric air, water bodies of water, soil: State sanitary rules and norms of DSanPiN 8.8.1.2.3.4-000-2001]. Resolution of the Chief State Sanitary Doctor of Ukraine of September 20, 2001 No. 137. 2001. 244 p. (in Ukrainian).

4. 4. Rafalsky V.V. Perelik pestytsidiv i agrokhimikativ, dozvolenikh do vykorystannia v Ukraini [List of pesticides and agrochemicals authorized for use in Ukraine]. In: Rafalsky V.V., Vashchenko V.M., Tchaikovsky V.V. et al. Catalog Ministry of Ecology and Natural Resources of Ukraine. Kiev: Univest Media; 2018, 1040 p. (in Ukrainian).

5. 5. Shvartau V.V. Gerbitsydy. Osnovy reguliatsii fitotoksychnosti ta fizyko-himichni i biologichni vlastivosti [Herbicides. Fundamentals of phytotoxicity regulation and physicochemical and biological properties: in 2 volumes]. Shvartau V.V., eds. Kiev: Logos; 2009, 1040 p. (in Ukrainian).

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