Physicochemical properties as a function of lomefloxacin biological activity-Reference-Cited by-同舟云学术

Physicochemical properties as a function of lomefloxacin biological activity

Published:2024 Issue:2 Volume:52 Page:197-202
ISSN:1426-9686
Container-title:Polski Merkuriusz Lekarski
language:en
Short-container-title:

Author:

Naser Noor H.¹,Suhail Falah S.A.²,Hussein Sahar A.³,Salih Shakir Shinawa²

Affiliation:

1. AL-ZAHRAA UNIVERSITY FOR WOMEN, KARBALA, IRAQ

2. THE ISLAMIC UNIVERSITY, NAJAF, IRAQ

3. KUFA UNIVERSITY, NAJAF, IRAQ

Abstract

Aim: The goal is to discover QSAR of Lomefloxacin as antibacterial activity. Materials and Methods: A number of lomefloxacins analogs activities were studied by program Windows Chem SW. The analogues were obtained and energy minimization was carried out through Molecular Modeling Program, the calculations were performed using General Atomic and Molecular Electronic Structure System (GAMESS) software. Results: There were six descriptions (N-quinoline more (-) ev charge, Kinetic Energy, Potential Energy, Log p, Log S, F6 charge) results have highly compatible of physicochemical properties with lomefloxacin analogs activities. It can be used to estimate the activities depending on QSAR equation of lomefloxacin analogs. Conclusions: The parameters used for calculation were depending on the quantum chemical was employed in deriving from computational study of properties and can used to predict the activities of certain analogs of Lomefloxacins as antibacterial compounds.

Publisher

ALUNA

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