Determination of the combined influence of alcohol abuse and hiv infection on the immunohistochemical indicators of the uterine tube receptors

Abstract

In the practice of doctors of many specialties, immunohistochemical research methods are widely used. The aim of our work was to determine the combined effect of alcohol abuse and HIV infection on the immunohistochemical parameters of fallopian tube receptors. We have studied sectional material obtained from 100 women of reproductive age (from 20 to 40 years). The received materials were divided into 4 groups. The first group consisted of sectional material of 25 women who had confirmed HIV infection. The second group included sectional material of 25 women suffering from chronic alcoholism. The third group consisted of a sectional material of 25 women in whom HIV infection was combined with alcoholism. The fourth (control) group included sectional material of 25 women without HIV infection and alcoholism. The result of the study shows that the balance between the processes of apoptosis and anti-apoptosis is disturbed in all three studied groups, while the phenomena of apoptosis prevail in the group of people suffering from alcoholism. At the same time, the processes of anti-apoptosis are most suppressed in HIV-infected women. The processes of stress restructuring of the fallopian tube were most pronounced in the group of women who abused alcohol. We concluded that the combined effect of alcohol abuse and HIV infection leads to a significant change in the immunohistochemical parameters of the fallopian tube tissue receptors. Keywords: chronic alcoholism, HIV infection, fallopian tube.