Mechanisms of formation of tubulointerstitional renal impairment at the initial stages of experimental diabetes mellitus

Author:

Olenovych O.A.1ORCID

Affiliation:

1. Bukovinian State Medical University, Chernivtsi, Ukraine

Abstract

Tubulointerstitial disorders were studied in 11-day long experimental alloxan-induced diabetes mellitus. We concluded that changes in the concentration gradients of sodium and potassium are already observed at the early stages of pathology and indicate the initiation of tubular dysfunction accompanied by intensification of natriuresis and kaliuresis. Despite regulatory control of the renal countercurrent multiplication system and intensification of sodium and potassium reabsorption at the level of the ascending Henle loop, further progression of tubulopathy, in addition to the relative insufficiency of the proximal and distal tubules, will result in the disturbance of hormonal-dependent reabsorption of cations, inhibition of aldosterone- and vasopressin-dependent mechanisms of interstitial osmolarity regulation with the development of tubulointerstitial disorders that unable adequate osmotic concentration of urine. Keywords: experimental diabetes mellitus, alloxan, concentration gradient of sodium and potassium, tubulointerstitial renal impairment.

Publisher

Kharkiv National Medical University

Subject

General Earth and Planetary Sciences,General Environmental Science

Reference8 articles.

1. Shamkhalova, M.Sh., Kurumova, K.O., & Shestakova, M.V. (2009). Faktory tubulointerstitsialnoho porazheniia pochek pri sakhamom diabete [Factors of tubulointerstitial lesions in diabetic kidneys]. Sakharnyi diabet - Diabetes Mellitus, 12(4), pp. 61-65. DOI: 10.14341/2072-0351-5707 [in russian].

2. Bondar’, I.A., & Klimontov, V.V. (2008). Tubulointerstitsial’nyy fibroz pri diabeticheskoy nefropatii: mekhanizmy razvitiya і podkhody k lecheniyu [Tubulointerstitial fibrosis in diabetic nephropathy: mechanisms of development and approaches to treatment]. Sakharnyi diabet - Diabetes Mellitus, 11(2), pp. 11-15. DOI: 10.14341/2072-0351-5752 [in russian].

3. Vallon, V., & Thomson, S.C. (2012). Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney. Annu. Rev. Physiol., 74, pp. 351-375. DOI: 10.1146/annurev-physiol-020911-153333. PMID: 22335797.

4. Shiuk, O. (1981). Funktsionalnoie issledovaniie pochek [Examination of kidney function]. Prague: Avitsenum, 344 p. [in russian].

5. Mahalias, V.M., Mikhieiev, A.O., Rohovyi, Yu.Ye., Shcherbinina, A.V., Turchynets, T.H., & Chipko, T.M. (2001). Suchasni metodyky eksperymentalnykh ta klinichnykh doslidzhen tsentralnoi naukovo-doslidnoi laboratorii Bukovynskoi derzhavnoi medychnoi akademii: navchalno-metodychnyi posibnyk [Modern methods of experimental and clinical research of the central research laboratory of the Bukovinian State Medical Academy: training manual]. Chernivtsi: Bukovinian State Medical Academy, 42 p. [in Ukrainian].

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3