Endothelial dysfunction of women before and after correction of body composition

Abstract

The article is devoted to the peculiarities of endothelial dysfunction of women with different types of obesity before and after correction of body composition. The article is devoted to the peculiarities of endothelial dysfunction in women with different types of obesity before and after correction of body composition. Obesity as a polygenic disease is a progressive problem of society. Numerous studies of recent decades have been devoted to the influence of excessive weight on human health, which indicate that obesity is an independent risk factor for cardiovascular disease, characterized by high mortality. The degree of cardiovascular risk in obesity depends on the distribution of adipose tissue, and hence on the normal functioning of the endothelium, since endothelial dysfunction is one of the first triggers of cardiovascular disease. The author noted that endothelial function is the most important component of homeostasis, it allows controlling the state of the vascular bed and providing blood supply to the organs both under physiological conditions and under the influence of pathologic factors. Scientific studies have shown the need of studying the functions of the endothelium in different categories of patients, women in particular. Endothelial dysfunction has been identified as an early marker of the development and progression of cardiovascular disease and beside that, obesity as a chronic inflammatory condition also provokes dysregulation of vascular homeostasis and leads to impaired vasodilatory function of the endothelium. It has been found that the degree of cardiovascular risk in obesity depends on the distribution of adipose tissue, and therefore on the normal functioning of the endothelium. The dysfunction of endothelium is one of the first steps in the development of cardiovascular disease. The necessity of amplification a body composition program for women with different degrees of obesity has been proved. An analysis of endothelial function before and after the program of correction of body composition was done. The results of analysis proved that dosed exercise and a transition to a healthy diet have been shown an improvement of the endothelial function and the reduction of both total adipose tissue and visceral fat. Keywords: endothelial dysfunction, obesity, body fat composition, physical training, healthy diet.