Uveitis complicated by phthisis bulbi: hemodynamic parameters in the prediction of anterior-posterior eye size reduction

Abstract

Background. Phthisis bulbi is a serious complication of uveitis, causing vision loss and esthetic defects. Hemodynamic disorders can play an important role in the formation of this complication as a result of uveitis. We did not find data on predicting the progression of phthisis bulbi with a reduction in anterior-posterior size in the available literature. Aim. To analyze the possibility of predicting the reduction in the anterior-posterior size of the eye with uveitis, complicated by phthisis bulbi, based on hemodynamic parameters Materials and Methods. 33 patients aged 5–84 years, of them 19 male and 14 female patients, with unilateral endogenous uveitis, complicated by phthisis bulbi, were examined. 15 patients with uveitis complicated by phthisis bulbi, who had not received any treatment during this time, were examined in dynamics (for at least 1 year). All patients underwent Doppler ultrasound examination of the ophthalmic artery and short posterior ciliary arteries. In addition, all patients underwent biomicroscopic and tonometric examinations, ultrasound biomicroscopy, rheoophthalmography of eyeballs, A-scan and B-scan ultrasonography. The results of the examination of eyes with uveitis complicated by phthisis bulbi were compared with the results of the examination of paired (healthy) eyes of the same patients. Results. We have developed a multiple regression model that allows us to predict a reduction in the anterior-posterior size of the eye with phthisis bulbi due to uveitis. The dynamics of the disease in 15 patients not taking any treatment for uveitis, has been monitored for more than a year. The prediction of phthisis bulbi progression was confirmed in 13 patients, which amounts to 86.7% (p<0.05). Conclusions. We have proposed a model that allows predicting the progressive or stationary course of phthisis bulbi due to uveitis based on hemodynamic parameters. Keywords: infectious uveitis, noninfectious uveitis, phthisis bulbi hemodynamic disorders, anterior-posterior size of the eyeball.