Author:
CAO Fu-jiang,FENG Shi-qing
Abstract
Objective
To review the recent studies about human umbilical cord mesenchymal stem cells (hUCMSCs) and advances in the treatment of spinal cord injury.
Data sources
Published articles (1983-2007) about hUCMSCs and spinal cord injury were selected using Medline.
Study selection
Articles selected were relevant to development of mesenchymal stem cells (MSCs) for transplantation in spinal cord injury therapy. Of 258 originally identified articles 51 were selected that specifically addressed the stated purpose.
Results
Recent work has revealed that hUCMSCs share most of the characteristics with MSCs derived from bone marrow and are more appropriate to transplantation for cell based therapies.
Conclusions
Human umbilical cord could be regarded as a source of MSCs for experimental and clinical needs. In addition, as a peculiar source of stem cells, hUCMSCs may play an important role in the treatment of spinal cord injury.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Cited by
40 articles.
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