An Update on the Epidemiology of Aspirin-Exacerbated Respiratory Disease

Abstract

Background Aspirin-exacerbated respiratory disease (AERD) is a disorder of nasal polyposis, asthma, and hypersensitivity respiratory reactions when on systemic cyclooxygenase 1 blockade. Methods AERD Warrants Specific Evaluation As An Endotype Of Asthma And Chronic Sinus Disease Due To Unique Therapeutic Opportunities. Currently, Aspirin Therapy Is Uniquely Beneficial As An Anti-Inflammatory Therapy In Aerd, With Multiple Additional Therapies Currently In Early To Late Clinical Studies, Which Might Also Show Exceptional Benefit In AERD. Results Yet, given the lack of a simple diagnostic test, opportunities to identify patients with AERD are still frequently neglected. Conclusion Identifying the prevalence and population characteristics necessary to determine appropriate candidates in whom to perform diagnostic aspirin challenge remains critically important and was the purpose of this article.