Monoclonal Antibody Therapy in Sinonasal Disease-Reference-Cited by-同舟云学术

Monoclonal Antibody Therapy in Sinonasal Disease

Published:2017-03 Issue:2 Volume:31 Page:93-95
ISSN:1945-8924
Container-title:American Journal of Rhinology & Allergy
language:en
Short-container-title:Am J Rhinol�Allergy

Author:

Chiarella Sergio E.¹,Sy Hendrik²,Peters Anju T.¹

Affiliation:

1. Division of Allergy-Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

2. Charité, University Medicine Berlin, Berlin, Germany

Abstract

Chronic rhinosinusitis (CRS) affects 12.5% of the U.S. population. CRS can be divided into CRS with nasal polyps (CRSwNP) and CRS without nasal polyps. Some individuals with CRSwNP do not respond to standard-of-care medical and surgical management. For these individuals, targeted biologic agents are emerging as an important therapeutic alternative. In this review, we described the most-relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-interleukin 5 (mepolizumab and reslizumab), and anti-interleukin 4/interleukin 13 (dupilumab) monoclonal antibodies for the treatment of CRSwNP. In addition, we discussed the importance of some of these clinical trials in identifying new CRS endotypes based on distinct inflammatory profiles.

Publisher

SAGE Publications

Subject

General Medicine,Otorhinolaryngology,Immunology and Allergy

Link

http://journals.sagepub.com/doi/pdf/10.2500/ajra.2017.31.4412

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