Current and future management of chronic spontaneous urticaria and chronic inducible urticaria

Author:

Do Toan T.1,Canty Ethan A.2,Joshi Shyam R.3

Affiliation:

1. From the Department of Internal Medicine, Oregon Health and Science University, Portland, Oregon

2. Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, and

3. Section of Allergy and Clinical Immunology, Oregon Health and Science University, Portland, Oregon

Abstract

Background: Chronic urticaria (CU), characterized by ≥6 weeks of intense pruritus, remains a debilitating condition for patients. New and safe treatments are needed to manage CU recalcitrant to standard therapy. Objective: A review of the current literature of standard and novel therapeutics in the management of CU was conducted. Methods: A literature search via a medical literature data base and clinical trial data base was conducted to identify treatment options for CU and current clinical trials. Results: Second-generation antihistamines, omalizumab, and cyclosporine remain the most proven therapeutic options for CU. Dupilumab, mepolizumab, benralizumab, tezepelumab, and CDX-0159 are all undergoing clinical trials for CU. Although ligelizumab demonstrated initial promising results, a phase III study was discontinued due to a nonsuperior clinical impact compared with omalizumab. Conclusion: Novel therapies are needed for the treatment of recalcitrant CU. With a deeper understanding of the pathophysiology of CU, promising therapeutics are in clinical trials for CU.

Publisher

Oceanside Publications Inc.

Subject

Pulmonary and Respiratory Medicine,General Medicine,Immunology and Allergy

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