In Vitro and in Vivo Antigen-Induced Release of High-Molecular Weight Neutrophil Chemotactic Activity from Human Nasal Tissue-Reference-Cited by-同舟云学术

In Vitro and in Vivo Antigen-Induced Release of High-Molecular Weight Neutrophil Chemotactic Activity from Human Nasal Tissue

Published:1988-01 Issue:1 Volume:2 Page:7-11
ISSN:1050-6586
Container-title:American Journal of Rhinology
language:en
Short-container-title:American Journal of Rhinology

Author:

Nagakura T.¹,Onda T.¹,likura Y.¹,Endo T.²,Nagakura H.²,Masaki T.³,Nagai H.⁴

Affiliation:

1. Department of Allergy, National Children's Medical Research Center, 3-35-31, Taishido, Setagaya-ku, Toyko 154, Japan

2. Department of Otorhinolaryngology, Jikei Medical School

3. Department of Pediatrics, Jikei Medical School

4. Department of Pharmacology, Gifu Pharmaceutical University

Abstract

High molecular weight neutrophil chemotactic activity has been identified in resected human nasal polyps, inferior turbinates, and nasal secretions following antigen challenge. The estimated molecular weight, by gel filtration chromatography, was approximately 600,000. However, a heterogeneity of molecular weight in some patients was recognized. Our results suggest a possible role for high molecular weight-neutrophil chemotactic activity in the pathogenesis of hypersensitivity in the human nasal cavity.

Publisher

SAGE Publications

Subject

Otorhinolaryngology

Link

http://journals.sagepub.com/doi/pdf/10.2500/105065888781693221

Reference14 articles.

1. Mediators of Anaphylaxis, Anaphylactoid Reactions, and Rhinitis

2. Neutrophil chemotactic factor of anaphylaxis

3. Neutrophil Chemotactic Activity in Antigen-Induced Late Asthmatic Reactions

4. Release of Neutrophil Chemotactic Activity during Immediate Hypersensitivity Reactions in Humans

5. Cold Urticaria

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1. Observations on the Response of the Nasal Mucosa to Allergens;Otolaryngology–Head and Neck Surgery;1994-09

2. Neutrophil chemotactic activity (NCA) in nasal secretions from atopic and nonatopic subjects.;Allergy;1993-08

3. ALLERGEN IMMUNOTHERAPY FOR THE PATIENT WITH ALLERGIC RHINITIS;Immunology and Allergy Clinics of North America;1992-02

4. The nasal allergic reaction: observations on the role of histamine;Clinical Experimental Allergy;1991-05

5. Release of high-molecular-weight neutrophil chemotactic activity from resected human nasal turbinate after antigen challenge;Journal of Allergy and Clinical Immunology;1989-03