A systematic analysis of vascular paroxysm pathophysiology in perimenopause: methods for nutritional correction

Abstract

Materials and Methods. A systematic analysis of publications retrieved from PubMed/MEDLINE database as well as in the list of primary sources of the identified scientific papers was carried out by using current methods for large data analysis within the framework of topological and metric approaches applied for data recognition/classification. A map of molecular-pathophysiological processes was compiled followed by performing analysis of metric condensations.Results. Three clusters of terms describing an impact of various biological processes into the pathophysiology of hot flushes were identified: inflammation combined with insulin resistance (cluster 1), the presence of chronic comorbid pathologies in patients (cluster 2), and disorders of serotonin metabolism (cluster 3). The use of menopausal hormone therapy (MHT) is not accepted for all patients. A promising direction in treatment of mild and moderate hot flushes is based on using nutraceuticals: vitamins, trace elements and substances obtained from plant extracts (isoflavones, phytoestrogens, etc.). Here, this set of interactions between pathophysiology of hot flushes and deficiency of certain micronutrients, inflammation, insulin resistance, chronic comorbid pathologies and disorders of serotonin metabolism is described. Replenished deficiency of vitamins C, E, A, B2, PP, B6, B12, and folates aids to reduce chronic inflammation, insulin resistance and normalize functioning of the autonomic nervous system. Natural and synthetic agonists of GABA receptors and tryptophan derivatives are necessary for serotonin biosynthesis and elimination of other neurotransmitter imbalances in order to normalize activity of the hypothalamic thermoregulatory region.Conclusion. Plant isoflavones (including phytoestrogens) together with vitamins and other micronutrients help to overcome estrogen-dependent withdrawal symptoms and eliminate dysfunction of autonomic nervous system