Functioning of the ADAMTS-13/vWF axis and its clinical significance-Reference-Cited by-同舟云学术

Functioning of the ADAMTS-13/vWF axis and its clinical significance

Published:2023-03-04 Issue:1 Volume:17 Page:127-137
ISSN:2500-3194
Container-title:Obstetrics, Gynecology and Reproduction
language:
Short-container-title:Akušerstvo, ginekologiâ i reprodukciâ

Author:

Grigoreva K. N.¹^ORCID,Gashimova N. R.¹^ORCID,Bitsadze V. O.¹^ORCID,Pankratyeva L. L.²^ORCID,Khizroeva J. Kh.¹^ORCID,Tretyakova M. V.¹^ORCID,Gris J.-C.³^ORCID,Malikova A. E.¹,Blinov D. V.⁴^ORCID,Tsibizova V. I.⁵^ORCID,Degtyareva N. D.¹^ORCID,Martirosyan S. V.⁶,Makatsariya A. D.¹^ORCID

Affiliation:

1. Sechenov University

2. Sechenov University; Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Health Ministry of Russian Federation; Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department

3. Sechenov University; University of Montpellier

4. Sechenov University; Institute for Preventive and Social Medicine; Moscow Haass Medical – Social Institute

5. Almazov National Medical Research Centre, Health Ministry of Russian Federation

6. Vorokhobov City Clinical Hospital № 67, Moscow Healthcare Department

Abstract

Advances in biology have allowed us to substantially deepen our knowledge about hemostasis functioning both in health and disease. ADAMTS-13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13) and von Willebrand factor (vWF) are components of the hemostasis system, which physiological interaction holds an important place in maintaining homeostasis. ADAMTS-13 is a metalloproteinase mainly acting to release vWF fragments into the blood plasma, as well as regulating its activity by cleaving ultra-large vWF multimers (UL-vWF) into smaller and less active forms. The study of such factors is of great clinical importance, since a decrease in ADAMTS-13 activity and an increase in vWF level can be predictors of microcirculatory disorders that play an important role in developing multiple organ failure. However, very few and fully contradictory studies devoted to the physiological aspects of the ADAMTS-13/vWF axis functioning in the mother–fetus system are available, therefore requiring to be further investigated.

Publisher

IRBIS

Subject

Obstetrics and Gynecology,Embryology,Reproductive Medicine

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