Epigenetic aspects in rehabilitation of female cancer patients-Reference-Cited by-同舟云学术

Epigenetic aspects in rehabilitation of female cancer patients

Published:2022-07-28 Issue:2 Volume:15 Page:294-303
ISSN:2070-4933
Container-title:FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology
language:
Short-container-title:Farmakoèkonomika

Author:

Solopova A. G.¹^ORCID,Blinov D. V.²^ORCID,Demyanov S. V.¹^ORCID,Demyanov G. V.¹^ORCID,Achkasov E. E.¹^ORCID,Vlasina A. Yu.¹^ORCID,Sandzhieva L. N.¹^ORCID,Ampilogova D. M.¹^ORCID

Affiliation:

1. Sechenov University

2. Institute for Preventive and Social Medicine; Lapino Clinical Hospital, Medical Group “Mother and Child”; Moscow Haass Medical Social Institute

Abstract

The influence of epigenetic processes on the development of malignant diseases, including gynaecological cancers, is now beyond doubt. DNA methylation, histone modification and post-transcriptional regulation by microRNAs lead to changes in the activity of various genes, contributing to female genital cancers (cervix, endometrium, ovarian). It should be noted that disruptions in gene expression do not only occur in malignant cells, but also in the tumour microenvironment, resulting in disease progression and relapse. However, “epigenetic markers” of carcinogenesis can be useful in the treatment and rehabilitation of patients, making a personalized approach possible.

Publisher

IRBIS

Subject

Public Health, Environmental and Occupational Health,Health Policy,Pharmacology

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