Author:
Farah Fahmi J.,Chiles Christopher D.
Abstract
Primary malignant cardiac lymphomas associated with grafts are extremely rare: to our knowledge, only 6 cases of prosthesis-associated B-cell lymphoma have been reported. Ours is the first report of recurrent diffuse large B-cell lymphoma associated with aortic valve allografts.
We treated a 60-year-old man who presented in early 2007 with aortic valve endocarditis. He underwent aortic valve replacement with an allograft; the resected native valve showed active endocarditis without tumor. In January 2011, the patient underwent repeat aortic valve replacement because of symptomatic aortic regurgitation. The explanted valve specimen displayed diffuse large B-cell lymphoma. In September 2011, the patient presented with fever and a mass around the aortic valve. He died in January 2012. On autopsy, the explanted replacement valve displayed recurrent diffuse large B-cell lymphoma. The recurrent lymphoma on a new graft leads us to believe that this tumor is more aggressive than had been thought. We propose early systemic chemotherapy, in addition to tumor resection, for the possibility of a better prognosis. We discuss our patient's case and review the relevant medical literature.
Publisher
Texas Heart Institute Journal
Subject
Cardiology and Cardiovascular Medicine
Reference12 articles.
1. Surgical treatment for primary lymphoma of the heart simulating prosthetic mitral valve thrombosis;Albat;J Thorac Cardiovasc Surg,1994
2. Primary cardiac lymphoma;Curtsinger;Cancer,1989
3. Clinical perspectives of primary cardiac lymphoma;Gowda;Angiology,2003
4. Is Dacron carcinogenic? Apropos of a case and review of the literature [in French];Durrleman;Arch Mal Coeur Vaiss,2004
5. Unusual presentation of primary cardiac lymphoma;Bagwan;Interact Cardiovasc Thorac Surg,2009
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献