In silico assessment of drug safety in human heart applied to late sodium current blockers
Author:
Publisher
Informa UK Limited
Subject
Biochemistry,Biophysics
Link
http://www.tandfonline.com/doi/pdf/10.4161/chan.24905
Reference80 articles.
1. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability
2. Pathophysiology and pharmacology of the cardiac “late sodium current”
3. Blocking Late Sodium Current Reduces Hydrogen Peroxide-Induced Arrhythmogenic Activity and Contractile Dysfunction
4. Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3
5. Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKrblockade
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