Conformational characterization of the charge variants of a human IgG1 monoclonal antibody using H/D exchange mass spectrometry
Author:
Publisher
Informa UK Limited
Subject
Immunology,Immunology and Allergy
Link
http://www.tandfonline.com/doi/pdf/10.4161/mabs.22695
Reference24 articles.
1. Fresh from the biologic pipeline-2009;Sheridan;Nat Biotechnol,2010
2. Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods;Vlasak;Curr Pharm Biotechnol,2008
3. Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats;Khawli;MAbs,2010
4. C-terminal lysine variants in fully human monoclonal antibodies: investigation of test methods and possible causes;Dick;Biotechnol Bioeng,2008
5. Analysis of lysine clipping of a humanized Lewis-Y specific IgG antibody and its relation to Fc-mediated effector function;Antes;J Chromatogr B Analyt Technol Biomed Life Sci,2007
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