Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1-Reference-Cited by-同舟云学术

Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1

Published:2013-11 Issue:11 Volume:14 Page:1050-1058
ISSN:1538-4047
Container-title:Cancer Biology & Therapy
language:en
Short-container-title:Cancer Biology & Therapy

Author:

Andrade-Vieira Rafaela,Han Jae H,Marignani Paola A

Publisher

Informa UK Limited

Subject

Cancer Research,Pharmacology,Oncology,Molecular Medicine

Link

http://www.tandfonline.com/doi/pdf/10.4161/cbt.26206

Reference48 articles.

1. mTOR links oncogenic signaling to tumor cell metabolism

2. mTOR Signaling in Growth Control and Disease

3. Marignani P, Sanchez-Cespedes M. The tumour suppressor role of LKB1 in human cancer. In: Lazo PA, ed. Emerging Signalling Pathways in Tumor Biology: Transworld Research Network., 2010:71-94.

4. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

5. The LKB1 tumor suppressor negatively regulates mTOR signaling

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