Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions-Reference-Cited by-同舟云学术

Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobic versus electrostatic inter-molecular interactions

Published:2015-01-02 Issue:1 Volume:7 Page:212-230
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Nichols Pilarin¹,Li Li¹,Kumar Sandeep²^ORCID,Buck Patrick M²³,Singh Satish K²,Goswami Sumit²,Balthazor Bryan²,Conley Tami R⁴⁵,Sek David¹,Allen Martin J⁶

Affiliation:

1. Biotherapeutics Pharmaceutical Sciences Research and Development; Pfizer Inc.; Andover, MA USA

2. Biotherapeutics Pharmaceutical Sciences Research and Development; Pfizer Inc.; Chesterfield, MO USA

3. Current affiliation for Patrick M Buck is Stephen M. Ross School of Business; University of Michigan; Ann Arbor, MI USA

4. Biotherapeutics Analytical Research and Development; Pfizer Inc.; Andover, MA USA

5. Current affiliation for Tami R Conley is Catalent Pharma Solutions; Morrisville, NC USA

6. Biotherapeutics BioProcess Research and Development; Pfizer Inc.; Chesterfield, MO USA

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

https://www.tandfonline.com/doi/pdf/10.4161/19420862.2014.985504

Reference52 articles.

1. Characterization and Suitability of Therapeutic Antibody Dense Phases for Subcutaneous Delivery

2. High-dose monoclonal antibodies via the subcutaneous route: challenges and technical solutions, an industry perspective

3. Viscosity Behavior of High-Concentration Protein Mixtures

4. Viscosity of concentrated therapeutic protein compositions

5. Reversible Self-Association Increases the Viscosity of a Concentrated Monoclonal Antibody in Aqueous Solution

Cited by 88 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A framework for the biophysical screening of antibody mutations targeting solvent-accessible hydrophobic and electrostatic patches for enhanced viscosity profiles;Computational and Structural Biotechnology Journal;2024-12

2. Leveraging Multi-Modal Feature Learning for Predictions of Antibody Viscosity;2024-09-01

3. Modulation of the high concentration viscosity of IgG ₁ antibodies using clinically validated Fc mutations;mAbs;2024-07-19

4. A First Insight into the Developability of an Immunoglobulin G3: A Combined Computational and Experimental Approach;ACS Pharmacology & Translational Science;2024-07-15

5. A first insight into the developability of an IgG3: A combined computational and experimental approach;2024-05-01