Oxidative Toxicity in Diabetes Mellitus: The Role of Nanoparticles and Future Therapeutic Strategies

Author:

Sabahi Mohammad Mahdi1ORCID,Ahmadi Sara Ami1,Mahjub Reza2ORCID,Ranjbar Akram3ORCID

Affiliation:

1. Hamadan University of Medical Sciences, Hamadan, ‎Iran

2. 3Department of Pharmaceutics, Hamadan University of Medical Sciences, Hamadan, ‎Iran

3. 4Department of Toxicology and Pharmacology, Hamadan University of Medical Sciences, Hamadan, Iran.

Abstract

Diabetes mellitus is one of the most common chronic medical conditions in the world. Increasing evidence suggests that chronic hyperglycemia can cause excessive production of free radicals, particularly reactive oxygen species (ROS). Free radicals play important roles in tissue damage in diabetes. The relationship between exposure to nanoparticles (NPs) and diabetes has been reported in many previous studies. Evaluation of the potential benefits and toxic effects of NPs on diabetic disorders is of importance. This review highlights studies on the relationship between NPs and oxidative stress (OS) as well as the possible mechanisms in diabetic animal models and humans.

Publisher

Andover House Inc

Subject

General Medicine

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