Affiliation:
1. New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA
2. Ehlers-Danlos Syndrome / Hypermobility Treatment Center, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, New York, USA
Abstract
Loeys–Dietz syndrome (LDS) is caused by connective tissue mutations; the resulting defective connective tissue in organs such as the eye may be related to ocular symptoms in patients with LDS. The aim of this study was to review different ocular manifestations in LDS. A literature review of articles published within the past 5 years was performed using Web of Science™ and PubMed to search for ‘Loeys–Dietz’ with the terms ‘ocular’ and ‘ophthalmology.’ Additional search terms were generated from the initial literature assessment, and 32 articles were ultimately reviewed. Reported ocular symptoms in LDS included hypertelorism, ocular misalignment, refractive errors, and more. For LDS, the most reported findings were hypertelorism (n=111), astigmatism (n=25), down slanting palpebral fissures (n=20), myopia (n=9), and strabismus (n=8). However, more research on ocular symptoms in LDS is needed.