Impact of TET2 Mutations on Haematopoietic Stem Cell Resilience to Immune-Related Stress
Author:
Affiliation:
1. Haematopoietic Stem Cell Laboratory, The Francis Crick Institute, London, UK
2. Plasticell Limited, Stevenage, UK
Publisher
European Medical Group
Reference8 articles.
1. Pan W et al. The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression. Immunity. 2017;47(2):284-97.e5.
2. Yura Y et al. clonal hematopoiesis: a new step linking inflammation to heart failure. JACC Basic to Transl Sci. 2020;5(2):196-207.
3. Cai Z et al. Inhibition of inflammatory signaling in Tet2 mutant preleukemic cells mitigates stress-induced abnormalities and clonal hematopoiesis. Cell Stem Cell. 2018;23(6):833-49.e5.
4. Huerga Encabo H et al. Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils. Cell Stem Cell. 2023;30(6):781-99.e9.
5. Calcagno DM et al. The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages. Sci Immunol. 2020;5(51):eaaz1974.
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