Are Successful Pregnancies an Achievable Goal in Patients with Chronic Myeloid Leukaemia?-Reference-Cited by-同舟云学术

Are Successful Pregnancies an Achievable Goal in Patients with Chronic Myeloid Leukaemia?

Published:2019-08-01 Issue: Volume: Page:80-84
ISSN:2053-6631
Container-title:EMJ Hematology
language:
Short-container-title:EMJ Hematol

Author:

Grudeva-Popova Zhanet¹,Spasov Emil²,Graklanov Vasko²,Sotirova Katya²,Popov Veselin¹,Balatzenko Gueorgui³,Hristova Ivanka⁴

Affiliation:

1. Department of Clinical Oncology, Medical University of Plovdiv, Plovdiv, Bulgaria 2. Saint George University Hospital for Active Treatment, Plovdiv, Bulgaria

2. Saint George University Hospital for Active Treatment, Plovdiv, Bulgaria; First Department of Internal Disease, Medical University of Plovdiv, Plovdiv, Bulgaria

3. Specialized Hospital for Active Treatment of Hematological Diseases, Sofia, Bulgaria

4. Saint George University Hospital for Active Treatment, Plovdiv, Bulgaria

Abstract

Since the late 1990s, when the first tyrosine kinase inhibitor (TKI) imatinib was introduced as a front-line treatment for chronic myeloid leukaemia, the disease’s course and prognosis has dramatically changed. The development of second-line and further-line more potent generations of TKI has further improved disease control and patients’ quality of life; however, during this time, many questions such as the duration of treatment, the depth of response, fertility, pregnancy, and family planning, have been raised. Recent prospective and retrospective discontinuation trials for TKI have shown encouraging results regarding the cessation of TKI treatment and maintaining complete molecular response. The authors report three cases of female patients diagnosed with chronic phase chronic myeloid leukaemia who achieved a long-term deep molecular response; had planned management during pregnancy, including regular molecular monitoring with or without INF-α; and all delivered healthy babies.

Publisher

European Medical Group

Subject

General Medicine

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