Renal Regeneration: Stem Cell-Based Therapies to Battle Kidney Disease-Reference-Cited by-同舟云学术

Renal Regeneration: Stem Cell-Based Therapies to Battle Kidney Disease

Published:2019-07-30 Issue: Volume: Page:54-64
ISSN:2053-4248
Container-title:EMJ Nephrology
language:
Short-container-title:EMJ Nephrol

Author:

Matsumoto Takuya¹,Schäffers Olivier J.M.¹,Yin Wenqing²,Morizane Ryuji³

Affiliation:

1. Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA

2. Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA

3. Renal Division, Brigham and Women’s Hospital, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts, USA

Abstract

While the worldwide prevalence of kidney disease is increasing rapidly, the current therapeutic repertoire for these patients is often limited to dialysis and organ transplantation. However, advances in developmental and stem cell biology have highlighted the potential of stem cells for the development of novel renal regeneration therapies. While there are currently no approved stem cell-based treatments for kidney disease, various types of stem cells have been shown to facilitate regeneration of kidney tissue in preclinical models of both acute and chronic kidney injury. This review summarises the current status of stem cell-based therapies to battle kidney disease. In addition, future directions for the clinical translation of stem cell research towards development of novel renal regeneration therapies are discussed.

Publisher

European Medical Group

Subject

General Medicine

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