Lymphatic Filariasis: An Immunologic Perspective-Reference-Cited by-同舟云学术

Lymphatic Filariasis: An Immunologic Perspective

Published:2021-08-20 Issue: Volume: Page:71-78
ISSN:2398-9130
Container-title:EMJ Allergy & Immunology
language:
Short-container-title:EMJ Allergy Immunol

Author:

Mandanas Joshua Angelo Hermida¹

Affiliation:

1. University of Perpetual Help, Dr. Jose G. Tamayo Medical University Santo Niňo, Biňan, Laguna, Philippines

Abstract

Introduction: This paper provides an overview of the current immunologic research findings of lymphatic filarial worms, which affect millions of people worldwide. Objectives: This paper aims to discuss the immunologic features of lymphatic filarial worms. It also aims to highlight their potential anti-inflammatory actions and the use of anti-filarial drugs against COVID-19. Methods: A literature review was performed to obtain insights on the immunologic features of lymphatic filarial worms. Results: The CD4+ (Th2) response profile is the main defence against filarial worms. Modulation of human immune responses are primarily mediated by parasite-secreted peptides. Lymphatic filarial worms have anti-inflammatory potentials. Drug repurposing of diethylcarbamazepine, doxycycline, and ivermectin can be looked upon against COVID-19. Conclusion: Lymphatic filarial worms have several immunologic effects on host immune systems, which promote chronic infection and curtail anti-inflammatory responses. Insights in this paper can serve as a guide for the understanding of immunologic aspects of lymphatic filarial worms.

Publisher

European Medical Group

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