A Review of Primary Immune Deficiency Disorders

Author:

Darian Talin1,`Freij Joudeh B1,Seth Divya2,Poowuttikul Pavadee2,Secord Elizabeth2

Affiliation:

1. Wayne State University School of Medicine, Detroit, Michigan, USA

2. Department of Pediatrics, Division of Allergy, Asthma and Immunology, Children’s Hospital of Michigan, Wayne State University, Detroit, Michigan, USA

Abstract

This scenario-based review of primary immunodeficiency diseases (PIDD) discusses the differential diagnosis, usual presentations, work-up, and treatment of children with the most commonly encountered immune disorders. Newborn screening (NBS) for severe combined immunodeficiency (SCID) is covered, as are later presenting disorders caused by B cell defects and disorders of the innate immune system.

Publisher

European Medical Group

Reference65 articles.

1. Justiz Vaillant AA, Qurie A, “Immunodeficiency,” StatPearls, 2020, Treasure Island: StatPearls Publishing. Available at: https://www.ncbi.nlm.nih.gov/books/NBK500027/. Last accessed: 15 May 2020.

2. Picard C et al. Primary immunodeficiencies: an update on the classification from the International Union of Immunological Societies Expert Committee for primary immunodeficiencies 2015. J Clin Immunol. 2015;35:696-726.

3. Jeffrey Modell Foundation. Available at: http://www.info4pi.org/. Last accessed: 22 May 2020.

4. American Academy of Allergy, Asthma, and Immunology. Available at: https://www.aaaai.org/. Last accessed: 22 May 2020.

5. Dalal I et al. The outcome of patients with hypogammaglobulinemia in infancy and early childhood. J Pediatr. 1998;133(1):144-6.

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