Diagnosis of Tuberculosis in Low-Resource Settings: Overcoming Challenges Within Laboratory Practice

Author:

Shaozae Chavini K1,Das Debjani1,Kumar Manoj1

Affiliation:

1. Department of Microbiology, Lady Hardinge Medical College and Associated SSK and KSC Hospitals, New Delhi, India

Abstract

Tuberculosis (TB), rightly referred to as an ancient disease, has affected humans for thousands of years, the first drafted reference of which came from India and China around 3,300 and 2,300 years ago, respectively. TB, caused by a bacillus called Mycobacterium tuberculosis, is a deadly infectious disease that is transmitted through aerosol droplets, and is estimated to have infected one-quarter of the global population. It has a mortality rate of 50% if treatment is not provided; however, with timely detection and interventions, which include currently recommended anti-TB drugs, 85% of people can be cured. India, being a resource-poor country, has one of the highest burdens of TB in the world, with an incidence of 210/100,000 in 2021, according to the World Health Organization (WHO) Global TB report of 2022.

Publisher

European Medical Group

Subject

General Medicine

Reference41 articles.

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2. World Health Organization (WHO). Global Tuberculosis Report 2022. 2022. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022. Last accessed: 14 May 2023.

3. Oommen S, Banaji N. Laboratory diagnosis of tuberculosis: advances in technology and drug susceptibility testing. Indian J Med Microbiol. 2017;35(3):323-31.

4. World Health Organization (WHO) Stop TB Partnership; Retooling Task Force. New laboratory diagnostic tools for tuberculosis control. 2008. Available at: https://apps.who.int/iris/bitstream/handle/10665/44036/9789241597487_eng.pdf. Last accessed: 14 May 2023.

5. Mase SR et al. Yield of serial sputum specimen examinations in the diagnosis of pulmonary tuberculosis: a systematic review. Int J Tuberc Lung Dis. 2007;11(5):485-95.

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