The Use of Frozen Embryo Transfer and the Development of Pregnancy-Induced Hypertension: A Literature Review

Abstract

The use of assisted reproduction techniques has been associated with obstetric complications. An understanding about which methods and treatment protocols produce better outcomes would provide greater opportunities for a successful pregnancy. The aim of this literature review was to identify whether frozen embryo transfer (FET) leads to a greater incidence of pregnancy-induced hypertension (PIH) compared to fresh embryo transfer. Fifteen studies were identified and subsequently reviewed. Eleven studies suggested FET increased the incidence of PIH–gestational hypertension and pre-eclampsia. The evidence suggests a correlation between FET and PIH. Exploration into why this is the case should be the focus of future studies. Implications for clinical practice involve extensive preconception counselling and potentially advising prophylactic low-dose aspirin with the aim of lower the incidence of PIH.